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Highlighted Publications
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Racial and socioeconomic factors are associated with cardiac DNA methylation among journals.physiology.org/doi/full/10.1152/ajpheart.00036.2021 men with end-stage heart failure.
Racial and socioeconomic factors are associated with cardiac DNA methylation among journals.physiology.org/doi/full/10.1152/ajpheart.00036.2021 men with end-stage heart failure.
Pepin ME, Ha CM, Backshi S, Potter L, Barchue SP, Asaad AH, Pogwizd SM, Pamboukian SV, Hidalgo B, Vickers SM, Wende AR.
Am J Physiol Heart Circ Physiol. 2021
Full List of Publications
Full List of Publications
“Fostering a Diverse Regional Community of Physician-Scientist Trainees.”
Pepin ME, Souder JP, Weaver AN, Lorenz RG, and Seay RL. Journal of the National Medical Association 2022
Identification of Nrf2-Responsive microRNA Networks as Putative Mediators of Myocardial Reductive Stress.
Quiles JM*, Pepin ME*, Challa AK, Mosbruger T, Hoidal JR, Wende AR, and Rajasekaran NS. Nature - Scientific Reports 2021
The aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia.
The aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia.
Pepin ME#, Schiano C., Miceli M., Benincasa G., Mansueto G., Grimwaldi V., Soricelli A., Wende A.R.# and Napoli C.# JECR 2021
Pepin ME#, Schiano C., Miceli M., Benincasa G., Mansueto G., Grimwaldi V., Soricelli A., Wende A.R.# and Napoli C.# JECR 2021
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.
Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. JAHA 2020
Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. JAHA 2020
Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction.
Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction.
Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. Diabetes 2020
Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. Diabetes 2020
Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells.
Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells.
Pepin ME#, Infante T, Benincasa G, Schiano C, Miceli M, Ceccarelli S, Megiorni F, Anastasiadou E, Della Valle G, Fatone G, Faenza M, Docimo L, Nicoletti GF, Marchese C, Wende AR, Napoli C*. Frontiers Genetics 2020
Pepin ME#, Infante T, Benincasa G, Schiano C, Miceli M, Ceccarelli S, Megiorni F, Anastasiadou E, Della Valle G, Fatone G, Faenza M, Docimo L, Nicoletti GF, Marchese C, Wende AR, Napoli C*. Frontiers Genetics 2020
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Pepin ME, Koentges C, Pfeil K, Gollmer J, Kersting S, Wiese S, Hoffmann MM, Odening KE, von Zur Muhlen C, Diehl P, Stachon P, Wolf D, Wende AR, Bode C, Zirlik A, Bugger H. Frontiers Endocrinology 2019
Pepin ME, Koentges C, Pfeil K, Gollmer J, Kersting S, Wiese S, Hoffmann MM, Odening KE, von Zur Muhlen C, Diehl P, Stachon P, Wolf D, Wende AR, Bode C, Zirlik A, Bugger H. Frontiers Endocrinology 2019
DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.
DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.
Pepin ME, Drakos S, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, Wende AR, Wever-Pinzon O. AJP Heart & Circ. Physiology 2019
Pepin ME, Drakos S, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, Wende AR, Wever-Pinzon O. AJP Heart & Circ. Physiology 2019
The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation.
The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation.
Webb WM, Irwin AB, Pepin ME, Henderson BW, Huang V, Butler AA, Herskowitz JH, Wende AR, Cash AE, Lubin FD. Journal of Biological Psychiatry 2019
Webb WM, Irwin AB, Pepin ME, Henderson BW, Huang V, Butler AA, Herskowitz JH, Wende AR, Cash AE, Lubin FD. Journal of Biological Psychiatry 2019
Gamification: An Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research Years.
Gamification: An Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research Years.
Pepin ME, Webb WM, Boppana S, Weaver AN, Seay RL, Dempsey DM, Willig JH, Geisler WM, Lorenz RG. Medical Science Educator 2019
Pepin ME, Webb WM, Boppana S, Weaver AN, Seay RL, Dempsey DM, Willig JH, Geisler WM, Lorenz RG. Medical Science Educator 2019
Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.
Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.
Pepin ME, Bickerton HH, Bethea M, Hunter CS, Wende AR, Banerjee RR. Endocrinology 2019
Pepin ME, Bickerton HH, Bethea M, Hunter CS, Wende AR, Banerjee RR. Endocrinology 2019
Epigenetics in the development of diabetic cardiomyopathy.
Epigenetics in the development of diabetic cardiomyopathy.
Pepin ME & Wende AR. Epigenomics 2019
Pepin ME & Wende AR. Epigenomics 2019
Resident macrophages reprogram toward a developmental state after acute kidney injury.
Resident macrophages reprogram toward a developmental state after acute kidney injury.
Lever JM, Hull TD, Boddu R, Pepin ME, Black LM, Adedoyin OO, Yang Z, Traylor AM, Jiang Y, Li Z, Peabody JE, Eckenrode HE, Crossman DK, Crowley MR, Bolisetty S, Zimmerman KA, Wende AR, Mrug M, Yoder BK, Agarwal A, George JF. JCI Insight 2019
Lever JM, Hull TD, Boddu R, Pepin ME, Black LM, Adedoyin OO, Yang Z, Traylor AM, Jiang Y, Li Z, Peabody JE, Eckenrode HE, Crossman DK, Crowley MR, Bolisetty S, Zimmerman KA, Wende AR, Mrug M, Yoder BK, Agarwal A, George JF. JCI Insight 2019
Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.
Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.
Pepin ME, Ha CM, Crossman DK, Litovsky SH, Varambally S, Barchue JP, Pamboukian SV, Diakos NA, Drakos SG, Pogwizd SM, Wende AR. Nature - Lab Invest.
Pepin ME, Ha CM, Crossman DK, Litovsky SH, Varambally S, Barchue JP, Pamboukian SV, Diakos NA, Drakos SG, Pogwizd SM, Wende AR. Nature - Lab Invest.
“Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.”
“Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.”
Kim T, Nason S, Holleman C, Pepin ME, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschop M, Habegger KM.
Kim T, Nason S, Holleman C, Pepin ME, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschop M, Habegger KM.
Diabetes 2018
Genetic and Epigenetic Underpinnings of End-Stage Human Heart Failure.
Genetic and Epigenetic Underpinnings of End-Stage Human Heart Failure.
Mark E. Pepin. ProQuest Dissertations 2019.
Mark E. Pepin. ProQuest Dissertations 2019.
Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance.
Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance.
Pepin ME, Padgett LE, McDowell RE, Burg AR, Brahma MK, Holleman C, Kim T, Crossman D, Kutsch O, Tse HM, Wende AR, Habegger KM. Molecular Metabolism 2018
Pepin ME, Padgett LE, McDowell RE, Burg AR, Brahma MK, Holleman C, Kim T, Crossman D, Kutsch O, Tse HM, Wende AR, Habegger KM. Molecular Metabolism 2018
Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.
Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.
Koentges C*, Pepin ME*, Musse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H. Basic Research in Cardiology 2017
Koentges C*, Pepin ME*, Musse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H. Basic Research in Cardiology 2017
Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.
Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.
Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED.Am J Physiol Heart Circ Physiol. 2017
Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED.Am J Physiol Heart Circ Physiol. 2017
Class-Wide Access to a Commercial Step 1 Question Bank During Preclinical Organ-Based Modules: A Pilot Project.
Class-Wide Access to a Commercial Step 1 Question Bank During Preclinical Organ-Based Modules: A Pilot Project.
Banos JH, Pepin ME, Van Wagoner N. Academic Medicine 2018
Banos JH, Pepin ME, Van Wagoner N. Academic Medicine 2018
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
Brahma MK, Pepin ME, Wende AR. Diabetes Metab J. 2017
Brahma MK, Pepin ME, Wende AR. Diabetes Metab J. 2017
Inhibition of myostatin signaling through Notch activation following acute resistance exercise.
Inhibition of myostatin signaling through Notch activation following acute resistance exercise.
MacKenzie MG, Hamilton DL, Pepin ME, Patton A, Baar K. PLoS One
MacKenzie MG, Hamilton DL, Pepin ME, Patton A, Baar K. PLoS One
Reversible control of electrochemical properties using thermally-responsive polymer electrolytes.
Reversible control of electrochemical properties using thermally-responsive polymer electrolytes.
Kelly JC, Pepin ME, Huber DL, Bunker BC, Roberts ME. Advanced Materials 2012
Kelly JC, Pepin ME, Huber DL, Bunker BC, Roberts ME. Advanced Materials 2012
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